Distinctive HBV Replication Capacity and Susceptibility to Tenofovir Induced by a Polymerase Point Mutation in Hepatoma Cell Lines and Primary Human Hepatocytes

Tenofovir disoproxil fumarate (TDF) has been regarded as the most potent drug for treating patients with chronic hepatitis B (CHB). However recently, viral mutations associated with tenofovir have been reported. Here, we found a CHB patient with suboptimal response after more than 4 years of TDF tre...

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Udgivet i:Int J Mol Sci
Main Authors: Lee, Ah Ram, Cho, Ju-Yeon, Kim, Jong Chul, Dezhbord, Mehrangiz, Choo, Soo Yeun, Ahn, Chang Hyun, Kim, Na Yeon, Shin, Jae Jin, Park, Soree, Park, Eun-Sook, Won, Juhee, Kim, Dong-Sik, Lee, Jeong-Hoon, Kim, Kyun-Hwan
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7914950/
https://ncbi.nlm.nih.gov/pubmed/33562603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22041606
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