Diverse genetic backgrounds play a prominent role in the metabolic phenotype of CC021/Unc and CC027/GeniUNC mice exposed to inorganic arsenic

Arsenic methyltransferase (AS3MT) is the key enzyme in the pathway for the methylation of inorganic arsenic (iAs), a potent human carcinogen and diabetogen. AS3MT converts iAs to mono- and dimethylated arsenic species (MAs, DMAs) that are excreted mainly in urine. Polymorphisms in AS3MT is a key gen...

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Veröffentlicht in:Toxicology
Hauptverfasser: Douillet, Christelle, Ji, Jinglin, Meenakshi, Immaneni Lakshmi, Lu, Kun, de Villena, Fernando Pardo-Manuel, Fry, Rebecca C., Stýblo, Miroslav
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7914223/
https://ncbi.nlm.nih.gov/pubmed/33524430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2021.152696
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