Design, Synthesis, and In Silico Multitarget Pharmacological Simulations of Acid Bioisosteres with a Validated In Vivo Antihyperglycemic Effect

Substituted phenylacetic (1–3), phenylpropanoic (4–6), and benzylidenethiazolidine-2,4-dione (7–9) derivatives were designed according to a multitarget unified pharmacophore pattern that has shown robust antidiabetic activity. This bioactivity is due to the simultaneous polypharmacological stimulati...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Domínguez-Mendoza, Elix Alberto, Galván-Ciprés, Yelzyn, Martínez-Miranda, Josué, Miranda-González, Cristian, Colín-Lozano, Blanca, Hernández-Núñez, Emanuel, Hernández-Bolio, Gloria I., Palomino-Hernández, Oscar, Navarrete-Vazquez, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7913794/
https://ncbi.nlm.nih.gov/pubmed/33557136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules26040799
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