Repeated Administration of Clinically Relevant Doses of the Prescription Opioids Tramadol and Tapentadol Causes Lung, Cardiac, and Brain Toxicity in Wistar Rats

Tramadol and tapentadol, two structurally related synthetic opioid analgesics, are widely prescribed due to the enhanced therapeutic profiles resulting from the synergistic combination between μ-opioid receptor (MOR) activation and monoamine reuptake inhibition. However, the number of adverse reacti...

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Detalhes bibliográficos
Publicado no:Pharmaceuticals (Basel)
Main Authors: Barbosa, Joana, Faria, Juliana, Garcez, Fernanda, Leal, Sandra, Afonso, Luís Pedro, Nascimento, Ana Vanessa, Moreira, Roxana, Pereira, Frederico C., Queirós, Odília, Carvalho, Félix, Dinis-Oliveira, Ricardo Jorge
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7912343/
https://ncbi.nlm.nih.gov/pubmed/33513867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14020097
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