Activation of NRF2 and ATF4 Signaling by the Pro-Glutathione Molecule I-152, a Co-Drug of N-Acetyl-Cysteine and Cysteamine

I-152 combines two pro-glutathione (GSH) molecules, namely N-acetyl-cysteine (NAC) and cysteamine (MEA), to improve their potency. The co-drug efficiently increases/replenishes GSH levels in vitro and in vivo; little is known about its mechanism of action. Here we demonstrate that I-152 not only sup...

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Detalhes bibliográficos
Publicado no:Antioxidants (Basel)
Main Authors: Crinelli, Rita, Zara, Carolina, Galluzzi, Luca, Buffi, Gloria, Ceccarini, Chiara, Smietana, Michael, Mari, Michele, Magnani, Mauro, Fraternale, Alessandra
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7911873/
https://ncbi.nlm.nih.gov/pubmed/33530504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox10020175
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