ADAM10-Mediated Cleavage of ICAM-1 Is Involved in Neutrophil Transendothelial Migration

To efficiently cross the endothelial barrier during inflammation, neutrophils first firmly adhere to the endothelial surface using the endothelial adhesion molecule ICAM-1. Upon actual transmigration, the release from ICAM-1 is required. While Integrin LFA1/Mac1 de-activation is one described mechan...

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Udgivet i:Cells
Main Authors: Morsing, Sofia K. H., Rademakers, Timo, Brouns, Sanne L. N., van Stalborch, Anne-Marieke D., Donners, Marjo M. P. C., van Buul, Jaap D.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7911467/
https://ncbi.nlm.nih.gov/pubmed/33504031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10020232
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