The metformin in tuberous sclerosis (MiTS) study: A randomised double-blind placebo-controlled trial

BACKGROUND: Tuberous Sclerosis Complex (TSC) is a genetic disorder characterised by the development of benign tumours secondary to loss of inhibitory regulation of the mTOR (mechanistic Target of Rapamycin) intracellular growth pathway. Metformin inhibits the mTOR pathway. We investigated whether me...

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Udgivet i:EClinicalMedicine
Main Authors: Amin, Sam, Mallick, Andrew A, Edwards, Hannah, Cortina-Borja, Mario, Laugharne, Matthew, Likeman, Marcus, O'Callaghan, Finbar J.K.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910694/
https://ncbi.nlm.nih.gov/pubmed/33681737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.eclinm.2020.100715
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