Aggresomes predict poor outcomes and implicate proteostasis in the pathogenesis of pediatric choroid plexus tumors

PURPOSE: Protein misfolding and aggregation result in proteotoxic stress and underlie the pathogenesis of many diseases. To overcome proteotoxicity, cells compartmentalize misfolded and aggregated proteins in different inclusion bodies. The aggresome is a paranuclear inclusion body that functions as...

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Detalhes bibliográficos
Publicado no:J Neurooncol
Main Authors: Amer, Nada, Taha, Hala, Hesham, Dina, Al-Shehaby, Nouran, Mosaab, Amal, Soudy, Mohamed, Osama, Aya, Mahmoud, Noura, Elayadi, Moatasem, Youssef, Ayda, Elbeltagy, Mohamed, Zaghloul, Mohamed Saad, Magdeldin, Sameh, Sayed, Ahmed A., El-Naggar, Shahenda
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2021
Assuntos:
Laboratory Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910251/
https://ncbi.nlm.nih.gov/pubmed/33501605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-020-03694-3
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