Aggresomes predict poor outcomes and implicate proteostasis in the pathogenesis of pediatric choroid plexus tumors

PURPOSE: Protein misfolding and aggregation result in proteotoxic stress and underlie the pathogenesis of many diseases. To overcome proteotoxicity, cells compartmentalize misfolded and aggregated proteins in different inclusion bodies. The aggresome is a paranuclear inclusion body that functions as...

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Udgivet i:J Neurooncol
Main Authors: Amer, Nada, Taha, Hala, Hesham, Dina, Al-Shehaby, Nouran, Mosaab, Amal, Soudy, Mohamed, Osama, Aya, Mahmoud, Noura, Elayadi, Moatasem, Youssef, Ayda, Elbeltagy, Mohamed, Zaghloul, Mohamed Saad, Magdeldin, Sameh, Sayed, Ahmed A., El-Naggar, Shahenda
Format: Artigo
Sprog:Inglês
Udgivet: Springer US 2021
Fag:
Laboratory Investigation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7910251/
https://ncbi.nlm.nih.gov/pubmed/33501605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-020-03694-3
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