Niclosamide suppresses the expansion of follicular helper T cells and alleviates disease severity in two murine models of lupus via STAT3

BACKGROUND: Autoantibody production against endogenous cellular components is pathogenic feature of systemic lupus erythematosus (SLE). Follicular helper T (T(FH)) cells aid in B cell differentiation into autoantibody-producing plasma cells (PCs). The IL-6 and IL-21 cytokine-mediated STAT3 signaling...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Jang, Se Gwang, Lee, Jaeseon, Hong, Seung-Min, Song, Young-Seok, Kim, Min Jun, Kwok, Seung-Ki, Cho, Mi-La, Park, Sung-Hwan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7908700/
https://ncbi.nlm.nih.gov/pubmed/33632240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-021-02760-2
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