Senescent cells promote tissue NAD(+) decline during ageing via the activation of CD38(+) macrophages

Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and its associated diseases. However, the mechanism for this decline is unclear. Here, we show that pro-inflammatory M1-like macrophages, but not naive or M2 macrophages, accumulate in metabolic tissues, including v...

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Veröffentlicht in:Nat Metab
Hauptverfasser: Covarrubias, Anthony J., Kale, Abhijit, Perrone, Rosalba, Lopez-Dominguez, Jose Alberto, Pisco, Angela Oliveira, Kasler, Herbert G., Schmidt, Mark S., Heckenbach, Indra, Kwok, Ryan, Wiley, Christopher D., Wong, Hoi-Shan, Gibbs, Eddy, Iyer, Shankar S., Basisty, Nathan, Wu, Qiuxia, Kim, Ik-Jung, Silva, Elena, Vitangcol, Kaitlyn, Shin, Kyong-Oh, Lee, Yong-Moon, Riley, Rebeccah, Ben-Sahra, Issam, Ott, Melanie, Schilling, Birgit, Scheibye-Knudsen, Morten, Ishihara, Katsuhiko, Quake, Stephen R., Newman, John, Brenner, Charles, Campisi, Judith, Verdin, Eric
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7908681/
https://ncbi.nlm.nih.gov/pubmed/33199924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-020-00305-3
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