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IgG-Engineered Protective Antigen for Cytosolic Delivery of Proteins into Cancer Cells

[Image: see text] Therapeutic immunotoxins composed of antibodies and bacterial toxins provide potent activity against malignant cells, but joining them with a defined covalent bond while maintaining the desired function is challenging. Here, we develop novel immunotoxins by dovetailing full-length...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Lu, Zeyu, Truex, Nicholas L., Melo, Mariane B., Cheng, Yiran, Li, Na, Irvine, Darrell J., Pentelute, Bradley L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7908032/
https://ncbi.nlm.nih.gov/pubmed/33655074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.0c01670
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