Impaired State-Dependent Potentiation of GABAergic Synaptic Currents Triggers Seizures in a Genetic Generalized Epilepsy Model

Epileptic activity in genetic generalized epilepsy (GGE) patients preferentially appears during sleep and its mechanism remains unknown. Here, we found that sleep-like slow-wave oscillations (0.5 Hz SWOs) potentiated excitatory and inhibitory synaptic currents in layer V cortical pyramidal neurons f...

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Detalhes bibliográficos
Publicado no:Cereb Cortex
Main Authors: Zhang, Chun-Qing, Catron, Mackenzie A, Ding, Li, Hanna, Caitlyn M, Gallagher, Martin J, Macdonald, Robert L, Zhou, Chengwen
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7906787/
https://ncbi.nlm.nih.gov/pubmed/32930324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhaa256
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