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Roflumilast Ameliorates Isoflurane-Induced Inflammation in Astrocytes via the CREB/BDNF Signaling Pathway
[Image: see text] Background and purpose: Astrocyte-mediated neuroinflammation plays an important role in anesthetic isoflurane-induced cognitive impairment. Roflumilast, a selective inhibitor of phosphodiesterase-4 (PDE-4) used for the treatment of chronic obstructive pulmonary disease (COPD), has...
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| Publicat a: | ACS Omega |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical Society
2021
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7906587/ https://ncbi.nlm.nih.gov/pubmed/33644540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.0c04799 |
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