Siplizumab Induces NK Cell Fratricide Through Antibody-Dependent Cell-Mediated Cytotoxicity

The glycoprotein CD2 is expressed on T and NK cells and contributes to cell-cell conjugation, agonistic signaling and actin cytoskeleton rearrangement. CD2 has previously been shown to have an important function in natural NK cell cytotoxicity but to be expendable in antibody-mediated cytotoxicity....

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Bibliographic Details
Published in:Front Immunol
Main Authors: Binder, Christian, Sellberg, Felix, Cvetkovski, Filip, Berg, Stefan, Berglund, Erik, Berglund, David
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2021
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904868/
https://ncbi.nlm.nih.gov/pubmed/33643309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.599526
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