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Enhancing KCC2 activity decreases hyperreflexia and spasticity after chronic spinal cord injury

After spinal cord injury (SCI), the majority of individuals develop spasticity, a debilitating condition involving involuntary movements, co-contraction of antagonistic muscles, and hyperreflexia. By acting on GABAergic and Ca(2+)-dependent signaling, current anti-spastic medications lead to serious...

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Detalhes bibliográficos
Publicado no:Exp Neurol
Main Authors: Bilchak, Jadwiga, Yeakle, Kyle, Caron, Guillaume, Malloy, Dillon, Côté, Marie-Pascale
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904648/
https://ncbi.nlm.nih.gov/pubmed/33453210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2021.113605
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