In-vitro evaluation of the immunomodulatory effects of Baricitinib: Implication for COVID-19 therapy

OBJECTIVE: Baricitinib seems a promising therapy for COVID-19. To fully-investigate its effects, we in-vitro evaluated the impact of baricitinib on the SARS-CoV-2-specific-response using the whole-blood platform. METHODS: We evaluated baricitinib effect on the IFN-γ-release and on a panel of soluble...

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Pubblicato in:J Infect
Autori principali: Petrone, Linda, Petruccioli, Elisa, Alonzi, Tonino, Vanini, Valentina, Cuzzi, Gilda, Najafi Fard, Saeid, Castilletti, Concetta, Palmieri, Fabrizio, Gualano, Gina, Vittozzi, Pietro, Nicastri, Emanuele, Lepore, Luciana, Grifoni, Alba, Antinori, Andrea, Vergori, Alessandra, Ippolito, Giuseppe, Cantini, Fabrizio, Goletti, Delia
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Authors. Published by Elsevier Ltd on behalf of The British Infection Association. 2021
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Commentary
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904476/
https://ncbi.nlm.nih.gov/pubmed/33639176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinf.2021.02.023
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