The deacetylation-phosphorylation regulation of SIRT2-SMC1A axis as a mechanism of antimitotic catastrophe in early tumorigenesis

Improper distribution of chromosomes during mitosis can contribute to malignant transformation. Higher eukaryotes have evolved a mitotic catastrophe mechanism for eliminating mitosis-incompetent cells; however, the signaling cascade and its epigenetic regulation are poorly understood. Our analyses o...

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Publicat a:Sci Adv
Autors principals: Yi, Fei, Zhang, Ying, Wang, Zhijun, Wang, Zhuo, Li, Ziwei, Zhou, Tingting, Xu, Hongde, Liu, Jingwei, Jiang, Bo, Li, Xiaoman, Wang, Liang, Bai, Ning, Guo, Qiqiang, Guan, Yi, Feng, Yanling, Mao, Zhiyong, Fan, Guangjian, Zhang, Shengping, Wang, Chuangui, Cao, Longyue, O’Rourke, Brian P., Wang, Yang, Wu, Yanmei, Wu, Boquan, You, Shilong, Zhang, Naijin, Guan, Junlin, Song, Xiaoyu, Sun, Yingxian, Wei, Shi, Cao, Liu
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7904255/
https://ncbi.nlm.nih.gov/pubmed/33627431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abe5518
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