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Activation of 5-HT7 receptor but not NOS is necessary for chronic 5-HT-induced hypotension

Low dose infusion of 5-hydroxytryptamine (5-HT) to rats causes both an acute and chronic fall in arterial blood pressure. The 5-HT(7) receptor subtype plays a critical part in the observed hypotension. Acute (minutes to hours) 5-HT infusion shows no depressor role for NO, but 5-HT depressor response...

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Bibliografske podrobnosti
izdano v:Exp Physiol
Main Authors: Seitz, Bridget M., Fink, Gregory D., Watts, Stephanie W.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7902303/
https://ncbi.nlm.nih.gov/pubmed/33052620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/EP088919
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