Growth Hormone Pulses and Liver Gene Expression Are Differentially Regulated by the Circadian Clock Gene Bmal1

In this study, we found that loss of the circadian clock gene Bmal1 causes disruptions throughout the growth hormone (GH) axis, from hepatic gene expression to production of urinary pheromones and pheromone-dependent behavior. First, we show that Bmal1 knockout (KO) males elicit reduced aggressive r...

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Bibliographic Details
Published in:Endocrinology
Main Authors: Schoeller, Erica L, Tonsfeldt, Karen J, Sinkovich, McKenna, Shi, Rujing, Mellon, Pamela L
Format: Artigo
Language:Inglês
Published: Oxford University Press 2021
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7901660/
https://ncbi.nlm.nih.gov/pubmed/33539533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/endocr/bqab023
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