Use of a molecular beacon based fluorescent method for assaying uracil DNA glycosylase (Ung) activity and inhibitor screening

Uracil DNA glycosylases are an important class of enzymes that hydrolyze the N-glycosidic bond between the uracil base and the deoxyribose sugar to initiate uracil excision repair. Uracil may arise in DNA either because of its direct incorporation (against A in the template) or because of cytosine d...

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Udgivet i:Biochem Biophys Rep
Main Authors: Mehta, Avani, Raj, Prateek, Sundriyal, Sandeep, Gopal, Balasubramanian, Varshney, Umesh
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900708/
https://ncbi.nlm.nih.gov/pubmed/33665381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2021.100954
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