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Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M

As transcription and replication use DNA as substrate, conflicts between transcription and replication can occur, leading to genome instability with direct consequences for human health. To determine how the two processes are coordinated throughout S phase, we characterize both processes together at...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Wang, Jianming, Rojas, Patricia, Mao, Jingwen, Mustè Sadurnì, Martina, Garnier, Olivia, Xiao, Songshu, Higgs, Martin R., Garcia, Paloma, Saponaro, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900609/
https://ncbi.nlm.nih.gov/pubmed/33596418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2021.108759
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