Silencing of the tRNA Modification Enzyme Cdkal1 Effects Functional Insulin Synthesis in NIT-1 Cells: tRNA(Lys3) Lacking ms(2)- (ms(2)t(6)A(37)) is Unable to Establish Sufficient Anticodon:Codon Interactions to Decode the Wobble Codon AAG

Human Genome Wide Association Studies found a significant risk of Type 2 Diabetes Mellitus (T2DM) in single nucleotide polymorphisms in the cdkal1 gene. The cdkal1 gene is remote from the insulin gene and with the surprising function of a specific tRNA modification. Population studies and case contr...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Narendran, Amithi, Vangaveti, Sweta, Ranganathan, Srivathsan V., Eruysal, Emily, Craft, Miranda, Alrifai, Omar, Chua, Fu Yee, Sarachan, Kathryn, Litwa, Breann, Ramachandran, Sheetal, Agris, Paul F.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Molecular Biosciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900539/
https://ncbi.nlm.nih.gov/pubmed/33634165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.584228
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