Conserved nicotine-activated neuroprotective pathways involve mitochondrial stress

Tobacco smoking is a risk factor for several human diseases. Conversely, smoking also reduces the prevalence of Parkinson’s disease, whose hallmark is degeneration of substantia nigra dopaminergic neurons (DNs). We use C. elegans as a model to investigate whether tobacco-derived nicotine activates n...

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Pubblicato in:iScience
Autori principali: Nourse, J. Brucker, Harshefi, Gilad, Marom, Adi, Karmi, Abdelrahaman, Cohen Ben-Ami, Hagit, Caldwell, Kim A., Caldwell, Guy A., Treinin, Millet
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900352/
https://ncbi.nlm.nih.gov/pubmed/33665559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102140
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