Causal role for sleep-dependent reactivation of learning-activated sensory ensembles for fear memory consolidation

Learning-activated engram neurons play a critical role in memory recall. An untested hypothesis is that these same neurons play an instructive role in offline memory consolidation. Here we show that a visually-cued fear memory is consolidated during post-conditioning sleep in mice. We then use TRAP...

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Udgivet i:Nat Commun
Main Authors: Clawson, Brittany C., Pickup, Emily J., Ensing, Amy, Geneseo, Laura, Shaver, James, Gonzalez-Amoretti, John, Zhao, Meiling, York, A. Kane, Kuhn, Femke Roig, Swift, Kevin, Martinez, Jessy D., Wang, Lijing, Jiang, Sha, Aton, Sara J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7900186/
https://ncbi.nlm.nih.gov/pubmed/33619256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21471-2
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