Titrating Growth Hormone Dose to High-Normal IGF-1 Levels Has Beneficial Effects on Body Fat Distribution and Microcirculatory Function Despite Causing Insulin Resistance

To clarify the mechanism underlying the described U-shaped relation of both low and high levels of IGF-1 with cardiovascular disease this study explores the effect of decreasing and increasing growth hormone dose in GH deficient adults on (micro)vascular function, body composition and insulin resist...

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Dettagli Bibliografici
Pubblicato in:Front Endocrinol (Lausanne)
Autori principali: van Bunderen, Christa C., Meijer, Rick I., Lips, Paul, Kramer, Mark H., Serné, Erik H., Drent, Madeleine L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Endocrinology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899963/
https://ncbi.nlm.nih.gov/pubmed/33633687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2020.619173
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