Proxalutamide Significantly Accelerates Viral Clearance and Reduces Time to Clinical Remission in Patients with Mild to Moderate COVID-19: Results from a Randomized, Double-Blinded, Placebo-Controlled Trial

Background The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into type II pneumocytes is dependent on a modification of viral spike proteins by transmembrane protease serine 2 (TMPRSS2) expressed on the surface of human cells. TMPRSS2 is regulated by the androgen receptor, he...

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Bibliographic Details
Published in:Cureus
Main Authors: Cadegiani, Flavio A, McCoy, John, Gustavo Wambier, Carlos, Vaño-Galván, Sergio, Shapiro, Jerry, Tosti, Antonella, Zimerman, Ricardo A, Goren, Andy
Format: Artigo
Language:Inglês
Published: Cureus 2021
Subjects:
Infectious Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7899267/
https://ncbi.nlm.nih.gov/pubmed/33633920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7759/cureus.13492
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