Synthesis of Asparagine Derivatives Harboring a Lewis X Type DC‐SIGN Ligand and Evaluation of their Impact on Immunomodulation in Multiple Sclerosis

The protein myelin oligodendrocyte glycoprotein (MOG) is a key component of myelin and an autoantigen in the disease multiple sclerosis (MS). Post‐translational N‐glycosylation of Asn(31) of MOG seems to play a key role in modulating the immune response towards myelin. This is mediated by the intera...

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Publicado no:Chemistry
Main Authors: Doelman, Ward, Marqvorsen, Mikkel H. S., Chiodo, Fabrizio, Bruijns, Sven C. M., van der Marel, Gijsbert A., van Kooyk, Yvette, van Kasteren, Sander I., Araman, Can
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7898482/
https://ncbi.nlm.nih.gov/pubmed/33090600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202004076
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