Cortical axonal loss is associated with both gray matter demyelination and white matter tract pathology in progressive multiple sclerosis: Evidence from a combined MRI-histopathology study

BACKGROUND: Neuroaxonal degeneration is one of the hallmarks of clinical deterioration in progressive multiple sclerosis (PMS). OBJECTIVE: To elucidate the association between neuroaxonal degeneration and both local cortical and connected white matter (WM) tract pathology in PMS. METHODS: Post-morte...

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Bibliographische Detailangaben
Veröffentlicht in:Mult Scler
Hauptverfasser: Kiljan, Svenja, Preziosa, Paolo, Jonkman, Laura E, van de Berg, Wilma DJ, Twisk, Jos, Pouwels, Petra JW, Schenk, Geert J, Rocca, Maria A, Filippi, Massimo, Geurts, Jeroen JG, Steenwijk, Martijn D
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2020
Schlagworte:
Original Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897796/
https://ncbi.nlm.nih.gov/pubmed/32390507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1352458520918978
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