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IL-15/IL-15Rα Heterodimeric Complex as Cancer Immunotherapy in Murine Breast Cancer Models

Interleukin 15 (IL-15) has been evaluated as a potential treatment for solid tumors in clinical trials, but the effectiveness of systemic IL-15 administration as a monotherapy has not been realized. IL-15 receptor alpha (IL-15Rα) can stabilize IL-15 and enhance its bioactivity. The goal of this stud...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Guo, Siqi, Smeltz, Ronald B., Nanajian, Anthony, Heller, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897681/
https://ncbi.nlm.nih.gov/pubmed/33628206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.614667
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