Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint

We have identified chemical probes that simultaneously inhibit cancer cell progression and an immune checkpoint. Using the computational Site Identification by Ligand Competitive Saturation (SILCS) technology, structural biology and cell-based assays, we identify small molecules that directly and se...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Solano-Gonzalez, Eduardo, Coburn, Katherine M, Yu, Wenbo, Wilson, Gerald M, Nurmemmedov, Elmar, Kesari, Santosh, Chang, Elizabeth T, MacKerell, Alexander D, Weber, David J, Carrier, France
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Chemical Biology and Nucleic Acid Chemistry
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897483/
https://ncbi.nlm.nih.gov/pubmed/33398344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa1254
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