Cross-comparison of human iPSC-derived motor neuron models of familial and sporadic ALS reveals early and convergent transcriptomic disease signatures

Induced pluripotent stem cell- (iPSC) derived neural cultures from amyotrophic lateral sclerosis (ALS) patients can model disease phenotypes. However, heterogeneity arising from genetic and experimental variability limits their utility, impacting reproducibility and the ability to track cellular ori...

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Detalhes bibliográficos
Publicado no:Cell Syst
Main Authors: Ho, Ritchie, Workman, Michael J., Mathkar, Pranav, Wu, Kathryn, Kim, Kevin J., O’Rourke, Jacqueline G., Kellogg, Mariko, Montel, Valerie, Banuelos, Maria G., Arogundade, Olubankole Aladesuyi, Diaz-Garcia, Sandra, Oheb, Daniel, Huang, Steven, Khrebtukova, Irena, Watson, Lisa, Ravits, John, Taylor, Kevin, Baloh, Robert H., Svendsen, Clive N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897311/
https://ncbi.nlm.nih.gov/pubmed/33382996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2020.10.010
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