Molecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success

Staphylococcus aureus causes invasive infections and easily acquires antibiotic resistance. Even antibiotic-susceptible S. aureus can survive antibiotic therapy and persist, requiring prolonged treatment and surgical interventions. These so-called persisters display an arrested-growth phenotype, tol...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Huemer, Markus, Mairpady Shambat, Srikanth, Bergada-Pijuan, Judith, Söderholm, Sandra, Boumasmoud, Mathilde, Vulin, Clément, Gómez-Mejia, Alejandro, Antelo Varela, Minia, Tripathi, Vishwachi, Götschi, Sandra, Marques Maggio, Ewerton, Hasse, Barbara, Brugger, Silvio D., Bumann, Dirk, Schuepbach, Reto A., Zinkernagel, Annelies S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2021
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7896289/
https://ncbi.nlm.nih.gov/pubmed/33574060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014920118
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