MTBP phosphorylation controls DNA replication origin firing

Faithful genome duplication requires regulation of origin firing to determine loci, timing and efficiency of replisome generation. Established kinase targets for eukaryotic origin firing regulation are the Mcm2-7 helicase, Sld3/Treslin/TICRR and Sld2/RecQL4. We report that metazoan Sld7, MTBP (Mdm2...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Ferreira, Pedro, Höfer, Verena, Kronshage, Nora, Marko, Anika, Reusswig, Karl-Uwe, Tetik, Bilal, Dießel, Christoph, Köhler, Kerstin, Tschernoster, Nikolai, Altmüller, Janine, Schulze, Nina, Pfander, Boris, Boos, Dominik
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895959/
https://ncbi.nlm.nih.gov/pubmed/33608586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83287-w
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