MTBP phosphorylation controls DNA replication origin firing

Faithful genome duplication requires regulation of origin firing to determine loci, timing and efficiency of replisome generation. Established kinase targets for eukaryotic origin firing regulation are the Mcm2-7 helicase, Sld3/Treslin/TICRR and Sld2/RecQL4. We report that metazoan Sld7, MTBP (Mdm2...

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Publié dans:Sci Rep
Auteurs principaux: Ferreira, Pedro, Höfer, Verena, Kronshage, Nora, Marko, Anika, Reusswig, Karl-Uwe, Tetik, Bilal, Dießel, Christoph, Köhler, Kerstin, Tschernoster, Nikolai, Altmüller, Janine, Schulze, Nina, Pfander, Boris, Boos, Dominik
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895959/
https://ncbi.nlm.nih.gov/pubmed/33608586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-83287-w
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