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Topologically associating domain boundaries that are stable across diverse cell types are evolutionarily constrained and enriched for heritability
Topologically associating domains (TADs) are fundamental units of three-dimensional (3D) nuclear organization. The regions bordering TADs—TAD boundaries—contribute to the regulation of gene expression by restricting interactions of cis-regulatory sequences to their target genes. TAD and TAD-boundary...
में बचाया:
| में प्रकाशित: | Am J Hum Genet |
|---|---|
| मुख्य लेखकों: | , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Elsevier
2021
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7895846/ https://ncbi.nlm.nih.gov/pubmed/33545030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2021.01.001 |
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