Poly(l-glutamic acid)-cisplatin nanoformulations with detachable PEGylation for prolonged circulation half-life and enhanced cell internalization

PEGylation has been widely applied to prolong the circulation times of nanomedicines via the steric shielding effect, which consequently improves the intratumoral accumulation. However, cell uptake of PEGylated nanoformulations is always blocked by the steric repulsion of PEG, which limits their the...

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Detaylı Bibliyografya
Yayımlandı:Bioact Mater
Asıl Yazarlar: Jiang, Zhongyu, Feng, Xiangru, Zou, Haoyang, Xu, Weiguo, Zhuang, Xiuli
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: KeAi Publishing 2021
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895728/
https://ncbi.nlm.nih.gov/pubmed/33665501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioactmat.2021.01.034
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