[D-Ala(2), D-Leu(5)] Enkephalin Inhibits TLR4/NF-κB Signaling Pathway and Protects Rat Brains against Focal Ischemia-Reperfusion Injury

BACKGROUND: Cerebral ischemia-reperfusion (I/R) injury is the main cause of acute brain injury, which is a life-threatening disease due to the lack of effective treatments. [D-Ala(2), D-Leu(5)] enkephalin (DADLE) is a synthetic delta-opioid receptor agonist that is reported to confer neuroprotective...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Fu, Danyun, Liu, Haitong, Zhu, Jiang, Xu, Hongjiao, Yao, Junyan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895595/
https://ncbi.nlm.nih.gov/pubmed/33628116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6661620
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