Dexmedetomidine Alleviates Hypoxia-Induced Synaptic Loss and Cognitive Impairment via Inhibition of Microglial NOX2 Activation in the Hippocampus of Neonatal Rats

BACKGROUND: Perinatal hypoxia is a universal cause of death and neurological deficits in neonates worldwide. Activation of microglial NADPH oxidase 2 (NOX2) leads to oxidative stress and neuroinflammation, which may contribute to hypoxic damage in the developing brain. Dexmedetomidine has been repor...

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Publicado en:Oxid Med Cell Longev
Main Authors: Chen, Xiaohui, Chen, Dongtai, Li, Qiang, Wu, Shuyan, Pan, Jiahao, Liao, Yanling, Zheng, Xiaochun, Zeng, Weian
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi 2021
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7895593/
https://ncbi.nlm.nih.gov/pubmed/33628369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6643171
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