Detection of EGFR Activating and Resistance Mutations by Droplet Digital PCR in Sputum of EGFR-Mutated NSCLC Patients

BACKGROUND: Proof of the T790M resistance mutation is mandatory if patients with EGFR-mutated non-small cell lung cancer (NSCLC) progress under first- or second-generation tyrosine kinase inhibitor therapy. In addition to rebiopsy, analysis of plasma circulating tumor DNA is used to detect T790M res...

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Veröffentlicht in:Clin Med Insights Oncol
Hauptverfasser: Hackner, Klaus, Buder, Anna, Hochmair, Maximilian J, Strieder, Matthaeus, Grech, Christina, Fabikan, Hannah, Burghuber, Otto C., Errhalt, Peter, Filipits, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2021
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7894584/
https://ncbi.nlm.nih.gov/pubmed/33642890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1179554921993072
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