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Stabilizing AqdC, a Pseudomonas Quinolone Signal‐Cleaving Dioxygenase from Mycobacteria, by FRESCO‐Based Protein Engineering
The mycobacterial PQS dioxygenase AqdC, a cofactor‐less protein with an α/β‐hydrolase fold, inactivates the virulence‐associated quorum‐sensing signal molecule 2‐heptyl‐3‐hydroxy‐4(1H)‐quinolone (PQS) produced by the opportunistic pathogen Pseudomonas aeruginosa and is therefore a potential anti‐vir...
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| Publicado no: | Chembiochem |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7894191/ https://ncbi.nlm.nih.gov/pubmed/33058333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000641 |
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