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High‐resolution three‐dimensional chromatin profiling of the Chinese hamster ovary cell genome
Chinese hamster ovary (CHO) cell lines are the pillars of a multibillion‐dollar biopharmaceutical industry producing recombinant therapeutic proteins. The effects of local chromatin organization and epigenetic repression within these cell lines result in unpredictable and unstable transgene expressi...
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| Publicado no: | Biotechnol Bioeng |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7894165/ https://ncbi.nlm.nih.gov/pubmed/33095445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.27607 |
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