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NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane

Isoprenylcysteine carboxyl methyltransferase (ICMT) is the third of three enzymes that sequentially modify the C-terminus of CaaX proteins, including RAS. Although all four RAS proteins are substrates for ICMT, each traffics to membranes differently by virtue of their hypervariable regions that are...

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Detalhes bibliográficos
Publicado no:Life Sci Alliance
Main Authors: Ahearn, Ian M, Court, Helen R, Siddiqui, Farid, Abankwa, Daniel, Philips, Mark R
Formato: Artigo
Idioma:Inglês
Publicado em: Life Science Alliance LLC 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7893820/
https://ncbi.nlm.nih.gov/pubmed/33579760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000972
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