Orexin-A alleviates cerebral ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress-mediated apoptosis

Orexin-A (OXA) protects neurons against cerebral ischemia-reperfusion injury (CIRI). Endoplasmic reticulum stress (ERS) induces apoptosis after CIRI by activating caspase-12 and the CHOP pathway. The present study aimed to determine whether OXA mitigates CIRI by inhibiting ERS-induced neuronal apopt...

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Publicado en:Mol Med Rep
Main Authors: Xu, Dandan, Kong, Tingting, Cheng, Baohua, Zhang, Rumin, Yang, Chunqing, Chen, Jing, Wang, Chunmei
Formato: Artigo
Idioma:Inglês
Publicado: D.A. Spandidos 2021
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7893697/
https://ncbi.nlm.nih.gov/pubmed/33576468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2021.11905
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