Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease

More than 240 genetic risk loci have been associated with inflammatory bowel disease (IBD), but little is known about how they contribute to disease development in involved tissue. Here, we hypothesized that host genetic variation affects gene expression in an inflammation-dependent way, and investi...

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Pubblicato in:Nat Commun
Autori principali: Hu, Shixian, Uniken Venema, Werna T., Westra, Harm-Jan, Vich Vila, Arnau, Barbieri, Ruggero, Voskuil, Michiel D., Blokzijl, Tjasso, Jansen, Bernadien H., Li, Yanni, Daly, Mark J., Xavier, Ramnik J., Dijkstra, Gerard, Festen, Eleonora A., Weersma, Rinse K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7892863/
https://ncbi.nlm.nih.gov/pubmed/33602935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21458-z
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