Inflammation status modulates the effect of host genetic variation on intestinal gene expression in inflammatory bowel disease

More than 240 genetic risk loci have been associated with inflammatory bowel disease (IBD), but little is known about how they contribute to disease development in involved tissue. Here, we hypothesized that host genetic variation affects gene expression in an inflammation-dependent way, and investi...

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Publicat a:Nat Commun
Autors principals: Hu, Shixian, Uniken Venema, Werna T., Westra, Harm-Jan, Vich Vila, Arnau, Barbieri, Ruggero, Voskuil, Michiel D., Blokzijl, Tjasso, Jansen, Bernadien H., Li, Yanni, Daly, Mark J., Xavier, Ramnik J., Dijkstra, Gerard, Festen, Eleonora A., Weersma, Rinse K.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2021
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7892863/
https://ncbi.nlm.nih.gov/pubmed/33602935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21458-z
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