Cellular senescence impairs the reversibility of pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) in congenital cardiac shunts can be reversed by hemodynamic unloading (HU) through shunt closure. However, this reversibility potential is lost beyond a certain point in time. The reason why PAH becomes irreversible is unknown. In this study, we used MCT+shunt-i...

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Published in:Sci Transl Med
Main Authors: van der Feen, Diederik E., Bossers, Guido P. L., Hagdorn, Quint A. J., Moonen, Jan-Renier, Kurakula, Kondababu, Szulcek, Robert, Chappell, James, Vallania, Francesco, Donato, Michele, Kok, Klaas, Kohli, Jaskaren S., Petersen, Arjen H., van Leusden, Tom, Demaria, Marco, Goumans, Marie-José T. H., De Boer, Rudolf A., Khatri, Purvesh, Rabinovitch, Marlene, Berger, Rolf M. F., Bartelds, Beatrijs
Format: Artigo
Language:Inglês
Published: 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7891555/
https://ncbi.nlm.nih.gov/pubmed/32727916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaw4974
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