Reprogramming of glutamine metabolism via glutamine synthetase silencing induces cisplatin resistance in A2780 ovarian cancer cells

BACKGROUND: Cisplatin (CDDP) significantly prolongs survival in various cancers, but many patients also develop resistance that results in treatment failure. Thus, this study aimed to elucidate the underlying mechanisms by which ovarian cancer cells acquire CDDP resistance. METHODS: We evaluated the...

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Publicat a:BMC Cancer
Autors principals: Guo, Jing, Satoh, Kiyotoshi, Tabata, Sho, Mori, Masaru, Tomita, Masaru, Soga, Tomoyoshi
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7891143/
https://ncbi.nlm.nih.gov/pubmed/33596851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-021-07879-5
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