Reprogramming of glutamine metabolism via glutamine synthetase silencing induces cisplatin resistance in A2780 ovarian cancer cells

BACKGROUND: Cisplatin (CDDP) significantly prolongs survival in various cancers, but many patients also develop resistance that results in treatment failure. Thus, this study aimed to elucidate the underlying mechanisms by which ovarian cancer cells acquire CDDP resistance. METHODS: We evaluated the...

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Vydáno v:BMC Cancer
Hlavní autoři: Guo, Jing, Satoh, Kiyotoshi, Tabata, Sho, Mori, Masaru, Tomita, Masaru, Soga, Tomoyoshi
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7891143/
https://ncbi.nlm.nih.gov/pubmed/33596851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-021-07879-5
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