The Recurrent Mutation in PATL2 Inhibits Its Degradation Thus Causing Female Infertility Characterized by Oocyte Maturation Defect Through Regulation of the Mos-MAPK Pathway

PAT1 homolog 2 (PATL2), encoding an RNA-binding protein, is a repressor involved in the translational regulation of maternal mRNAs during oocyte maturation. Previous studies have reported mutations in PATL2 those led to female infertility with oocyte maturation arrest; however, the mechanisms by whi...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Cao, Qiqi, Zhao, Chun, Wang, Congjing, Cai, Lingbo, Xia, Meng, Zhang, Xiaolan, Han, Jian, Xu, Yangyang, Zhang, Junqiang, Ling, Xiufeng, Ma, Xiang, Huo, Ran
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7890943/
https://ncbi.nlm.nih.gov/pubmed/33614659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2021.628649
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