Efficacy of metformin and fermentable fiber combination therapy in adolescents with severe obesity and insulin resistance: study protocol for a double-blind randomized controlled trial

BACKGROUND: Accumulating evidence suggests that the metabolic effects of metformin and fermentable fibers are mediated, in part, through diverging or overlapping effects on the composition and metabolic functions of the gut microbiome. Pre-clinical animal models have established that the addition of...

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Detalhes bibliográficos
Publicado no:Trials
Main Authors: Deehan, Edward C., Colin-Ramirez, Eloisa, Triador, Lucila, Madsen, Karen L., Prado, Carla M., Field, Catherine J., Ball, Geoff D. C., Tan, Qiming, Orsso, Camila, Dinu, Irina, Pakseresht, Mohammadreza, Rubin, Daniela, Sharma, Arya M., Tun, Hein, Walter, Jens, Newgard, Christopher B., Freemark, Michael, Wine, Eytan, Haqq, Andrea M.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Study Protocol
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7890810/
https://ncbi.nlm.nih.gov/pubmed/33596993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-021-05060-8
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