Systematic improvements in lentiviral transduction of primary human natural killer cells undergoing ex vivo expansion

Transduction of primary human natural killer (NK) cells with lentiviral vectors has historically been challenging. We sought to evaluate multiple parameters to optimize lentiviral transduction of human peripheral blood NK cells being expanded to large numbers using a good manufacturing practice (GMP...

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Bibliografski detalji
Izdano u:Mol Ther Methods Clin Dev
Glavni autori: Allan, David S.J., Chakraborty, Mala, Waller, Giacomo C., Hochman, Michael J., Poolcharoen, Akkapon, Reger, Robert N., Childs, Richard W.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Gene & Cell Therapy 2021
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Original Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7890427/
https://ncbi.nlm.nih.gov/pubmed/33665226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2021.01.008
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