Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions

Liquid–liquid phase separation of proteins underpins the formation of membraneless compartments in living cells. Elucidating the molecular driving forces underlying protein phase transitions is therefore a key objective for understanding biological function and malfunction. Here we show that cellula...

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Publicado no:Nat Commun
Main Authors: Krainer, Georg, Welsh, Timothy J., Joseph, Jerelle A., Espinosa, Jorge R., Wittmann, Sina, de Csilléry, Ella, Sridhar, Akshay, Toprakcioglu, Zenon, Gudiškytė, Giedre, Czekalska, Magdalena A., Arter, William E., Guillén-Boixet, Jordina, Franzmann, Titus M., Qamar, Seema, George-Hyslop, Peter St, Hyman, Anthony A., Collepardo-Guevara, Rosana, Alberti, Simon, Knowles, Tuomas P. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889641/
https://ncbi.nlm.nih.gov/pubmed/33597515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21181-9
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