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Fusaric acid decreases p53 expression by altering promoter methylation and m6A RNA methylation in human hepatocellular carcinoma (HepG2) cells

Fusaric acid (FA) is a food-borne mycotoxin that mediates toxicity with limited information on its epigenetic properties. p53 is a tumour suppressor protein that regulates cell cycle arrest and apoptotic cell death. The expression of p53 is regulated transcriptionally by promoter methylation and pos...

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Pubblicato in:Epigenetics
Autori principali: Ghazi, Terisha, Nagiah, Savania, Chuturgoon, Anil A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7889137/
https://ncbi.nlm.nih.gov/pubmed/32631113
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2020.1788324
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